The Pilot and Feasibility Program awards four annual grants to Northwestern University faculty. The program is funded through designated grant support of the Administrative Core, as well as from the Feinberg School of Medicine Dean’s office and the Department of Dermatology. Awards are established on an annual basis by the Pilot and Feasibility committee. If sufficient scientific progress is demonstrated over the grant year, it is possible that an award may be renewed for no more than one additional year. The studies are designed to:
- Foster research about keratinocytes leading to sufficient preliminary data for procurement of federal funding
- Attract established investigators to pursue research related to skin biology
- Encourage collaborative opportunities between the Department of Dermatology and other departments within the medical school and the university
- Provide mentorship in grant writing as well as feedback regarding the conduct of scientific investigation for more junior scientists
All recipients of Pilot and Feasibility awards automatically become Core Members during their funding period and retain membership if they continue research in cutaneous biology. Submissions to the Pilot and Feasibility Committee are requested campus-wide every spring. Starting with the 2014-2015 academic year, it has been determined that one of the four awards will be granted to a project focusing on a problem which addresses minority or sex issues in cutaneous biology research.
Keratinocyte Mitochondria as Systemic Oxygen Sensor
The Role of Keratinocytes as Independent Thermosensors
The Effect of IL-4 Receptor Signaling on Inflammation and Skin Barrier Function in Atopic Dermatitis
Nanoparticle Delivery of Oligonucleotides Targeting Missense Mutations in Keratinocytes
Mechanisms Underlying Adverse Cutaneous Effects Of The Anti-Cancer Drug, Bortezomib
The regulation of cell migration and intercalation through keratinocytes
Keratinocyte innate immune responses after herpes simplex virus infection
Innate immune host defense function of Keratinocytes
Study of keratinocyte biology from kidney transplant patients with different skin types.
Gold nanoparticles loaded with cobalt schiff base-DNA conjugates for specific and activatable inhibition of Gli transcription factors.
Determining the role of CRAC channels for calcium dynamics and effector function in keratinocytes.
Functional Analysis of T Cell Transcription Factors in the Immune Regulation of Skin Inflammation
Sexually dimorphic effects of topical glucocorticoids
Nuclear Polarity during Epidermal Differentiation
Targeting a bacterial Ras-Specific protease to treat skin diseases
Lipid Antigen-Specific T Cells in Chronic Skin Inflammatory Diseases
For additional information on the P&F Program, contact Robert M. Lavker, PhD.